Removal of T cells by various methods in different lupus prone mouse models including the MRL/lpr model results in decreased IgG production, decreased nephritis and increased/prolonged survival [31C35]. exhibited significantly decreased TCR-specific activation during early disease compared to T cells. Moreover, the T cells expressed significantly less neuraminidase 1 (T cells. FLI1 dose-dependently activated the … Continue reading Removal of T cells by various methods in different lupus prone mouse models including the MRL/lpr model results in decreased IgG production, decreased nephritis and increased/prolonged survival [31C35]